Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stability

doi:10.1002/bit.28399

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Article

Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stability

15 Apr 2023

Abstract excerpt

Phenotypic stability of Chinese hamster ovary (CHO) cells over long term culture (LTC) presents one of the most pressing challenges in the development of therapeutic protein manufacturing processess. However, our current understanding of the consequences of LTC on recombinant (r-) CHO cell lines is still limited, particularly as clonally-derived cell lines present distinct production stability phenotypes. This...

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PMID: 37060548
DOI: 10.1002/bit.28399

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