Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines

4 May 2022

Abstract excerpt

The biomanufacturing industry is advancing toward continuous processes that will involve longer culture durations and older cell ages. These upstream trends may bring unforeseen challenges for downstream purification due to fluctuations in host cell protein (HCP) levels. To understand the extent of HCP expression instability exhibited by Chinese hamster ovary (CHO) cells over these time scales, an industry-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35508759
DOI: 10.1002/bit.28128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell linesPMID 35508759Read ↗

Expression of difficult‐to‐remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessingSemantic proximity Read ↗

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO CellsSemantic proximity Read ↗

Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levelsSemantic proximity Read ↗

Identification and classification of host cell proteins during biopharmaceutical process developmentSemantic proximity Read ↗

Proteomics Reveals Distinctive Host Cell Protein Expression Patterns in Fed‐Batch and Perfusion Cell Culture ProcessesSemantic proximity Read ↗

Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis.Semantic proximity Read ↗

Diversity in host clone performance within a <scp>C</scp> hinese hamster ovary cell lineSemantic proximity Read ↗

A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques.Semantic proximity Read ↗

Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traitsSemantic proximity Read ↗

Proteomic Analysis of Bioreactor Cultures of an Antibody Expressing CHOGS Cell Line that Promotes High ProductivitySemantic proximity Read ↗

Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturingSemantic proximity Read ↗

More similar than different: Host cell protein production using three null CHO cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.