Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIF-1 Signaling Pathway Implicated in Phenotypic Instability in a Chinese Hamster Ovary Production Cell Line.

Biotechnology journal - 1 Apr 2020

Lieske Paulena L, Wei Wei, Crowe Kerstin B, Figueroa Bruno, Zhang Lin

Abstract excerpt

Monitoring genotypic and phenotypic stability is crucial during the development of recombinant Chinese hamster ovary (CHO) cell lines. Although genotypic instability is well-studied, there are few reports on phenotypic instability. Here, a case study of two clonal cell lines derived from Pfizer's site-specific integration expression platform that expresses the same monoclonal antibody is described. It is shown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Glycolysis

Share to Hypoxia-Inducible Factor 1

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Sequence Analysis, RNA

Source

Identifiers

PMID: 31872551
DOI: 10.1002/biot.201900306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIF-1 Signaling Pathway Implicated in Phenotypic Instability in a Chinese Hamster Ovary Production Cell Line.PMID 31872551Read ↗

Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stabilitySemantic proximity Read ↗

Pyruvate Kinase Muscle‐1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case StudySemantic proximity Read ↗

Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traitsSemantic proximity Read ↗

Recombinant antibody-producing stable CHOK1 pool stability studySemantic proximity Read ↗

Antibody expression stability in CHO clonally derived cell lines and their subclones: Role of methylation in phenotypic and epigenetic heterogeneity.Semantic proximity Read ↗

Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell linesSemantic proximity Read ↗

Proteome analysis of antibody‐producing CHO cell lines with different metabolic profilesSemantic proximity Read ↗

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures.Semantic proximity Read ↗

Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line.Semantic proximity Read ↗

High-Antibody-Producing Chinese Hamster Ovary Cells Up-Regulate Intracellular Protein Transport and Glutathione SynthesisSemantic proximity Read ↗

Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.Semantic proximity Read ↗

Utilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.