Article
Genetic stability of protein expression systems in yeast.
Developments in biological standardization - 1 Jan 1994
Bussineau C M, Shuster J R
Abstract excerpt
For the expression of recombinant proteins in yeast, genetic stability is monitored using a combination of standard microbiology and nucleic acid testing procedures. Process consistency during the cell amplification and product expression phases of fermentation are also reliable indicators of stability. The potential for instability arising from point mutation, gene conversion or recombination has been shown to...
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