Article
Hybridoma stability.
Developments in biological standardization - 1 Jan 1994
Castillo F J, Mullen L J, Grant B C, DeLeon J, Thrift J C, Chang L W, Irving J M, Burke D J
Abstract excerpt
Hybridoma stability issues include mutations, chromosome losses, and the potential effects of process variables on the yield, quality and homogeneity of the Monoclonal Antibody (MAb) product. MAb production by murine hybridomas is typically unstable in the early stages after fusion but repeated c...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Biotechnology
- CD5 Antigens
- Humans
- Hybridomas
- Immunoglobulin G
- Mice
- Mutation
- Peptide Mapping
- Quality Control
- Reproducibility of Results