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Article

Hybridoma stability.

Developments in biological standardization - 1 Jan 1994

Castillo F J, Mullen L J, Grant B C, DeLeon J, Thrift J C, Chang L W, Irving J M, Burke D J

Abstract excerpt

Hybridoma stability issues include mutations, chromosome losses, and the potential effects of process variables on the yield, quality and homogeneity of the Monoclonal Antibody (MAb) product. MAb production by murine hybridomas is typically unstable in the early stages after fusion but repeated cloning normally produces stable clones. The stability of hybridomas and the consistency of the MAbs produced during...

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PMID: 7533731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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