Alternative NF‐κB signaling regulates mTEC differentiation from podoplanin‐expressing precursors in the cortico‐medullary junction

Abstract excerpt

The thymic epithelium forms specialized niches to enable thymocyte differentiation. While the common epithelial progenitor of medullary and cortical thymic epithelial cells (mTECs and cTECs) is well defined, early stages of mTEC lineage specification have remained elusive. Here, we utilized in vivo targeting of mTECs to resolve their differentiation pathways and to determine whether mTEC progenitors participate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Childhood Cancer Survivors' Quality of Life
• Share to Lymphatic System and Diseases
• Share to Wnt/β-catenin signaling in development and cancer