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Article

Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation

9 Oct 2017

Abstract excerpt

Abstract The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII)lo to mature MHCIIhi mTECs has recently been extended to include a third stage, namely the post-Aire MHCIIlo subset as identified by lineage-tracing models. However, a suitable surface marker distinguishing the phenotypically overlapping pre- from the post-Aire...

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PMID: 28993517
DOI: 10.4049/jimmunol.1700203

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