The role of duplication of tumour-derived chromosome 15 carrying the rearranged pvt-1 gene in the transformed phenotype of YACUT T-cell lymphoma x G4 T-cell line somatic cell hybrids in dictating the terminal differentiation program of the parental G4 cell.

Abstract excerpt

Fusion of the YACUT T-cell lymphoma with the Mls-1a-antigen-specific non-tumorigenic T-cell line G4 was previously reported to produce growth-arrested hybrids that could be induced to proliferate in the presence of Mls-1a antigen. The proliferation-suppressed hybrid lines exhibited phenotypic changes as follows: the usually high levels in YACUT of J11d antigen, IL-2 receptor, and c-myb expression, which are...

Topics

• Animals
• Cell Differentiation
• Cell Division
• Cell Line, Transformed
• Chromosome Mapping
• Cytotoxicity, Immunologic
• Gene Rearrangement
• Hybridomas
• Lymphoma, T-Cell
• Mice