Article
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2001
Baldassarre G, Fedele M, Battista S, Vecchione A, Klein-Szanto A J, Santoro M, Waldmann T A, Azimi N, Croce C M, Fusco A
Abstract excerpt
Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that...
Topics
- Animals
- Cell Transformation, Neoplastic
- Genetic Predisposition to Disease
- High Mobility Group Proteins
- Humans
- Interleukin-15
- Interleukin-2
- Killer Cells, Natural
- Lymphoma, T-Cell