Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiation mechanisms and malignancy.

Biochemistry. Biokhimiia - 1 Jan 2000

Abelev G I

Abstract excerpt

This review considers the relationship between differentiation mechanisms and the genesis and maintenance of tumor phenotype. To a certain extent, carcinomas preserve differentiation markers of normal tissue, and hemoblastoses precisely reflect the direction and differentiation level of their precursor cells. Both tumor types retain the ability to differentiate. Mechanisms of T and B cell differentiation are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leukemia
Share to Carcinoma
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Disease Progression

Share to Immunophenotyping

Share to Lymphoma

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 10702645

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiation mechanisms and malignancy.PMID 10702645Read ↗

Introduction: oncogenes and differentiation.Semantic proximity Read ↗

Solid Tumor Differentiation Therapy - Is It Possible?Semantic proximity Read ↗

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.Semantic proximity Read ↗

Differentiation therapy for solid tumorsSemantic proximity Read ↗

Leukemic transformation.Semantic proximity Read ↗

Disruption of differentiation in human cancer: AML shows the way.Semantic proximity Read ↗

Differentiation therapy of human cancer: basic science and clinical applicationsSemantic proximity Read ↗

Regulation of differentiation, proliferation and cancer suppressor activity.Semantic proximity Read ↗

Chromatin modifying activity of leukaemia associated fusion proteinsSemantic proximity Read ↗

Mechanisms for the transformation of myeloid and erythroid cells by the nuclear oncogene V-myb.Semantic proximity Read ↗

Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations.Semantic proximity Read ↗

Molecular pathogenesis of T-cell leukaemia and lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.