Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

15 Jun 1999

Abstract excerpt

Chromosome translocations involving antigen receptor loci are a genetic hallmark of non-Hodgkin's lymphomas in humans. Most commonly, these translocations result in juxtaposition of the immunoglobulin heavy-chain (IgH) locus with one of several cellular proto-oncogenes, leading to deregulated oncogene expression. The V(D)J recombinase, which mediates physiologic rearrangements of antigen receptor genes, may play...

Source

Identifiers

PMID: 10377173
DOI: 10.1172/jci6658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinasePMID 10377173Read ↗

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse linesSemantic proximity Read ↗

RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaksSemantic proximity Read ↗

Array-CGH analyses of murine malignant lymphomas: genomic clues to understanding the effects of chronic exposure to low-dose-rate gamma rays on lymphomagenesis.Semantic proximity Read ↗

Mechanisms of chromosomal translocations in B cell lymphomas.Semantic proximity Read ↗

Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.Semantic proximity Read ↗

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene AmplificationSemantic proximity Read ↗

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read ↗

Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.Semantic proximity Read ↗

Identification of <i>IGHC</i>δ–<i>BACH2</i> fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B‐cell lymphoma/leukemiaSemantic proximity Read ↗

Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes.Semantic proximity Read ↗

Human common acute lymphoblastic leukemia-derived cell lines are competent to recombine their T-cell receptor delta/alpha regions along a hierarchically ordered pathway.Semantic proximity Read ↗

Role of the translocation partner in protection against AID-dependent chromosomal translocationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.