Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNase E mutant that functions in an anti-oxidant pathway.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2000

Nanbu-Wakao R, Asoh S, Nishimaki K, Tanaka R, Ohta S

Abstract excerpt

BACKGROUND: Bax is a member of the Bcl-2 family and induces apoptosis of mammalian cells. We have shown that a trace amount of human Bax induces the cell death of Escherichia coli, accompanied by damage to DNA, and that the region of Bax which is lethal to E. coli is also responsible for apoptosis-inducing activity in the mammalian cells. RESULTS: We isolated a Bax-resistant mutant from E. coli cells that survive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Gene Expression Regulation, Bacterial

Share to Gene Transfer Techniques

Share to Oxidative Stress

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 10759888
DOI: 10.1046/j.1365-2443.2000.00316.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNase E mutant that functions in an anti-oxidant pathway.PMID 10759888Read ↗

A trace amount of the human pro-apoptotic factor Bax induces bacterial death accompanied by damage of DNA.Semantic proximity Read ↗

Pore formation domain of human pro-apoptotic Bax induces mammalian apoptosis as well as bacterial death without antagonizing anti-apoptotic factors.Semantic proximity Read ↗

Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death.Semantic proximity Read ↗

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6.Semantic proximity Read ↗

Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death.Semantic proximity Read ↗

The Bcl-2 oncoprotein functions as a pro-oxidant.Semantic proximity Read ↗

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammationSemantic proximity Read ↗

Bax-induced cell death in tobacco is similar to the hypersensitive response.Semantic proximity Read ↗

Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast.Semantic proximity Read ↗

Active Bax and Bak are functional holins.Semantic proximity Read ↗

The Bax inhibitor MrBI-1 regulates heat tolerance, apoptotic-like cell death, and virulence in Metarhizium robertsii.Semantic proximity Read ↗

The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.