Article

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1996-01-01

Abstract excerpt

The BCL-2 gene was first discovered because of its involvement in the t(14;18) chromosomal translocations commonly found in lymphomas, which result in deregulation of BCL-2 gene expression and cause inappropriately high levels of Bcl-2 protein production. Expression of the BCL-2 gene can also become altered in human cancers through other mechanisms, including loss of the p53 tumor suppressor which normally functio...

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Literature Corpus work: 08511951-f5cb-5f6c-af37-9f70c554adbd
DOI: 10.1002/(sici)1097-4644(19960101)60:1<23::aid-jcb5>3.0.co;2-5

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