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Article

Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice.

Journal of neurochemistry - 1 Aug 1998

Hochman A, Sternin H, Gorodin S, Korsmeyer S, Ziv I, Melamed E, Offen D

Abstract excerpt

Bcl-2 is an antiapoptotic protein located in the outer mitochondrial membrane. Cellular perturbations associated with programmed cell death may be the consequence of disrupted mitochondrial function as well as excessive production of reactive oxygen species (ROS). Numerous studies indicate that Bcl-2 is involved in opposing cell death induced by oxidative stimuli, but its mode of action is uncertain. We...

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Identifiers

PMID: 9681465
DOI: 10.1046/j.1471-4159.1998.71020741.x

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