Article
Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice.
Journal of neurochemistry - 1 Aug 1998
Hochman A, Sternin H, Gorodin S, Korsmeyer S, Ziv I, Melamed E, Offen D
Abstract excerpt
Bcl-2 is an antiapoptotic protein located in the outer mitochondrial membrane. Cellular perturbations associated with programmed cell death may be the consequence of disrupted mitochondrial function as well as excessive production of reactive oxygen species (ROS). Numerous studies indicate that B...
Topics
- Animals
- Cells, Cultured
- Cerebellum
- Corpus Striatum
- Dopamine
- Glutathione Peroxidase
- Glutathione Reductase
- Glutathione Transferase
- Mice
- Mice, Knockout
- Mutagenesis
- Neurons
- Oxidants
- Oxidative Stress
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- Spleen