Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

Science (New York, N.Y.) - 19 Nov 1993

Taki S, Meiering M, Rajewsky K

Abstract excerpt

A mutant mouse strain has been generated in which a rearranged immunoglobulin heavy (H) chain variable (V) region gene is placed into the heavy chain locus in its natural position, replacing the JH elements. In homozygous mutant mice, essentially all B cells in the spleen express the transgenic VH region in their antibodies. The proper location of the transgene relative to the constant region genes allows it to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice, Transgenic
Share to Molecular Sequence Data
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Cells, Cultured

Share to Homozygote

Share to Mutation

Source

Identifiers

PMID: 8235657
DOI: 10.1126/science.8235657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.PMID 8235657Read ↗

Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.Semantic proximity Read ↗

Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin ĸ light chain genesSemantic proximity Read ↗

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.Semantic proximity Read ↗

The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strainsSemantic proximity Read ↗

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locusSemantic proximity Read ↗

Transgenic Mouse Strains as Platforms for the Successful Discovery and Development of Human Therapeutic Monoclonal AntibodiesSemantic proximity Read ↗

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes.Semantic proximity Read ↗

Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regionsSemantic proximity Read ↗

Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice.Semantic proximity Read ↗

Antibody repertoires generated by VH replacement and direct VH to JH joining.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.