Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

doi:10.1126/science.8235657

Back to search

Article

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.

Science (New York, N.Y.) - 19 Nov 1993

Taki S, Meiering M, Rajewsky K

Abstract excerpt

A mutant mouse strain has been generated in which a rearranged immunoglobulin heavy (H) chain variable (V) region gene is placed into the heavy chain locus in its natural position, replacing the JH elements. In homozygous mutant mice, essentially all B cells in the spleen express the transgenic V...

Topics

Amino Acid Sequence
Animals
B-Lymphocytes
Base Sequence
Cells, Cultured
Genes, Immunoglobulin
Homozygote
Immunoglobulin Class Switching
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.