Article
Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.
The Journal of biological chemistry - 8 Dec 2017
Takada Yoko K, Yu Jessica, Fujita Masaaki, Saegusa Jun, Wu Chun-Yi, Takada Yoshikazu
Abstract excerpt
There is a strong link between integrins and interleukin-1β (IL-1β), but the specifics of the role of integrins in IL-1β signaling are unclear. We describe that IL-1β specifically bound to integrins αvβ3 and α5β1. The E128K mutation in the IL1R-binding site enhanced integrin binding. We studied whether direct integrin binding is involved in IL-1β signaling. We compared sequences of IL-1β and IL-1 receptor...
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