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Article

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning.

Nature - 23 Feb 1995

Lepage T, Cohen S M, Diaz-Benjumea F J, Parkhurst S M

Abstract excerpt

Interaction between distinctly specified cells in adjacent compartments establishes organizing centres that control growth and specify cell fate in the developing limbs of Drosophila. Localized expression of the secreted Hedgehog protein (Hh) by cells in the posterior compartment induces expression of the secreted signalling molecules decapentaplegic (dpp) or wingless (wg) in nearby anterior cells. wg and dpp in...

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PMID: 7854456
DOI: 10.1038/373711a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning.PMID 7854456Read ↗

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Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development.Semantic proximity Read ↗

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs.Semantic proximity Read ↗

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.Semantic proximity Read ↗

Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.Semantic proximity Read ↗

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.Semantic proximity Read ↗

Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.Semantic proximity Read ↗

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.Semantic proximity Read ↗

Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed.Semantic proximity Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

Positional signaling by hedgehog in Drosophila imaginal disc development.Semantic proximity Read ↗

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