Article
Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin.
Cancer research - 1 Mar 1995
Harvey M, Vogel H, Lee E Y, Bradley A, Donehower L A
Abstract excerpt
To examine whether a cooperative role exists between inherited Rb and p53 deficiency in tumorigenesis, crosses were made between p53- and Rb-deficient mice and were monitored for subsequent tumor incidence and spectrum. Parental mice containing either Rb or p53 mutant alleles showed a predisposition for pituitary adenomas or lymphomas and sarcomas, respectively. Mice heterozygous for both Rb and p53 mutant...
Topics
- Adenocarcinoma
- Adenoma
- Alleles
- Animals
- Endocrine Gland Neoplasms
- Gene Deletion
- Genes, Retinoblastoma
- Genes, p53
- Heterozygote
- Mice
- Mice, Inbred Strains
- Mutation