Article
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
Molecular and cellular biology - 1 Dec 2004
Takahashi Chiaki, Contreras Bernardo, Bronson Roderick T, Loda Massimo, Ewen Mark E
Abstract excerpt
Although the retinoblastoma protein (pRb) has been implicated in the processes of cellular differentiation, there is no compelling genetic or in vivo evidence that such activities contribute to pRb-mediated tumor suppression. Motivated by cell culture studies suggesting that Ras is a downstream effector of pRb in the control of differentiation, we have examined the tumor and developmental phenotypes of Rb and...
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