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Article

Cooperative tumorigenic effects of germline mutations in Rb and p53.

Nature genetics - 1 Aug 1994

Williams B O, Remington L, Albert D M, Mukai S, Bronson R T, Jacks T

Abstract excerpt

The tumour suppressor genes Rb and p53 are mutated in several types of human cancer, and many tumour types carry mutations in both genes. To study how these genes normally function, we and others have created mouse strains with Rb and p53 mutations. Here we describe the phenotypic effects of comb...

Topics

Adenoma, Islet Cell
Animals
Brain Neoplasms
Bronchi
Crosses, Genetic
Female
Genes, Retinoblastoma
Genes, p53
Heterozygote
Homozygote
Humans
Hyperplasia
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Mutant Strains

Mutation

Neoplasms, Experimental

Organ Specificity

Source

Identifiers

PMID: 7951317
DOI: 10.1038/ng0894-480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7951317-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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