Article
Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 1995
Kamohara S, Hayashi H, Todaka M, Kanai F, Ishii K, Imanaka T, Escobedo J A, Williams L T, Ebina Y
Abstract excerpt
Insulin is the only known hormone which rapidly stimulates glucose uptake in target tissues, mainly by translocation to the cell surface of the intracellular insulin-regulatable glucose transporter (glucose transporter type 4, GLUT4). We have developed a cell line for direct, sensitive detection of GLUT4 on the cell surface. We have suggested that insulin-activated phosphatidylinositol (PI) 3-kinase may be...
Topics
- 3T3 Cells
- Animals
- Binding Sites
- Biological Transport
- CHO Cells
- Cricetinae
- Down-Regulation
- Enzyme Activation
- Glucose Transporter Type 4
- Insulin