Article
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.
Journal of cell science - 1 Dec 2004
Berwick Daniel C, Dell Ghislaine C, Welsh Gavin I, Heesom Kate J, Hers Ingeborg, Fletcher Laura M, Cooke Frank T, Tavaré Jeremy M
Abstract excerpt
Insulin-stimulated glucose uptake involves the recruitment of the glucose transporter 4 isoform (GLUT4) from an intracellular location to the plasma membrane of fat and muscle cells. Although the activation of the PI3-kinase/protein kinase B (PKB) pathway is central to this effect of insulin, the key substrates for PKB that are involved require identification. Here we report that serine318 on the FYVE...
Topics
- 3T3-L1 Cells
- Adipocytes
- Animals
- Biological Transport
- Blotting, Western
- CHO Cells
- Cell Membrane
- Cricetinae
- Endocytosis
- Glucose
- Glucose Transporter Type 4