Article
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.
Journal of cell science - 1 Dec 2004
Berwick Daniel C, Dell Ghislaine C, Welsh Gavin I, Heesom Kate J, Hers Ingeborg, Fletcher Laura M, Cooke Frank T, Tavaré Jeremy M
Abstract excerpt
Insulin-stimulated glucose uptake involves the recruitment of the glucose transporter 4 isoform (GLUT4) from an intracellular location to the plasma membrane of fat and muscle cells. Although the activation of the PI3-kinase/protein kinase B (PKB) pathway is central to this effect of insulin, the key substrates for PKB that are involved require identification. Here we report that serine318 on the FYVE...
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