Article
Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1999
Zhou L, Chen H, Xu P, Cong L N, Sciacchitano S, Li Y, Graham D, Jacobs A R, Taylor S I, Quon M J
Abstract excerpt
The insulin receptor initiates insulin action by phosphorylating multiple intracellular substrates. Previously, we have demonstrated that insulin receptor substrates (IRS)-1 and -2 can mediate insulin's action to promote translocation of GLUT4 glucose transporters to the cell surface in rat adipose cells. Although IRS-1, -2, and -4 are similar in overall structure, IRS-3 is approximately 50% shorter and differs...
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