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Article

Evolution in microcosm: the rapid somatic diversification of lymphocytes.

Annales d'immunologie - 1 Jan 2000

Cunningham A J

Abstract excerpt

The characteristic task of the immune system is learning to respond specificially to entirely novel antigens. How it may do this is discussed under 6 headings. 1. -- Vertebrate and invertebrate immune strategies are contrasted. Whereas among invertebrates whole individuals appear to be selected for their immunological fitness, vertebrates have developed an internal population of lymphocytes among which variants...

Topics

Aging
Animals
Antibody Specificity
Antibody-Producing Cells
Binding Sites, Antibody
Biological Evolution
Clone Cells
Cross Reactions
Genotype
Hemolytic Plaque Technique
Hybrid Cells
Invertebrates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Phenotype

Vertebrates

Source

Identifiers

PMID: 786145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-786145-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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