Article
MHC evolution and development of a recognition system.
Annals of the New York Academy of Sciences - 15 Apr 1994
Ohno S
Abstract excerpt
The unrestricted viability of allophenic mice shows that MHC-different cell lines have no problem engaging in organogenesis together. Thus, outside of the immune system, mammals appear to have no self-non-self discrimination mechanism based on polymorphic and ubiquitously expressed class I MHC antigens. Here, it should be pointed out that even within the immune system, certain responses require no self-non-self...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Biological Evolution
- Chick Embryo
- Histocompatibility Antigens Class I
- Humans
- Major Histocompatibility Complex
- Mice
- Molecular Sequence Data
- Oligopeptides
- T-Lymphocytes, Cytotoxic