p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

doi:10.1101/gad.9.2.204

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Article

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

Genes & development - 15 Jan 1995

Ewen M E, Oliver C J, Sluss H K, Miller S J, Peeper D S

Abstract excerpt

Transforming growth factor beta 1 (TGF-beta 1) can cause a cell-cycle arrest in G1. Inhibition of cyclin-dependent kinase 4 (cdk4) synthesis plays a significant role in the mechanism by which this cytokine causes G1 growth arrest. Deregulated expression of cdk4 confers resistance to TGF-beta 1. H...

Topics

Base Sequence
CDC2-CDC28 Kinases
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases
Down-Regulation
Drug Resistance
Enzyme Repression
Epithelial Cells
G1 Phase
Lung
Models, Biological
Molecular Sequence Data
Mutation
Protein Biosynthesis
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7851794
DOI: 10.1101/gad.9.2.204

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7851794-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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