Article
Adenovirus E1A antagonizes both negative and positive growth signals elicited by transforming growth factor beta 1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1995
de Groot R P, Kranenburg O, de Wit L, van den Eijnden-van Raaij J, Mummery C, van der Eb A J, Zantema A
Abstract excerpt
Transforming growth factor beta 1 (TGF beta 1) is a cytokine capable of inhibiting or stimulating cell growth, depending on the nature of the target cell. Inhibition of cell growth by TGF beta 1 is thought to be mediated by TGF beta 1-induced changes in the expression and activity of cell cycle r...
Topics
- 3T3 Cells
- Adenovirus E1A Proteins
- Animals
- Blotting, Northern
- Blotting, Western
- CDC2-CDC28 Kinases
- Cell Division
- Cells, Cultured
- Culture Media, Serum-Free
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinases
- Dose-Response Relationship, Drug