Article
MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p.
Human molecular genetics - 1 Oct 1994
Ueki K, Rubio M P, Ramesh V, Correa K M, Rutter J L, von Deimling A, Buckler A J, Gusella J F, Louis D N
Abstract excerpt
Human astrocytomas frequently have allelic losses of chromosome 9p, suggesting the presence of a 9p astrocytoma tumor suppressor gene. The MTS1 (or CDKN2) gene on chromosome 9p encodes a cell-cycle regulator and is deleted in approximately 80% of astrocytoma cell lines. To determine whether MTS1 is the tumor suppressor gene involved in human astrocytoma formation in vivo, we have analyzed chromosome 9p allelic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.