Homozygous Deletions of the <i>CDKN2C</i>/p 18^INK4C Gene on the Short Arm of Chromosome 1 in Anaplastic Oligodendrogliomas

Abstract excerpt

Allelic deletions of the short arm of chromosome 1 are common in oligodendrogliomas and have been correlated with chemosensitivity and better prognosis in patients with high-grade oligodendrogliomas. In these tumors, 1p loss is also inversely related to deletions of the CDKN2A gene on 9p, which encodes the key cell cycle regulatory molecule p16INK4A. Because the CDKN2C gene, which encodes the homologous p18INK4C...

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