Article
p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.
Molecular and cellular biology - 1 Feb 1999
Di Como C J, Gaiddon C, Prives C
Abstract excerpt
The p53 tumor suppressor protein, found mutated in over 50% of all human tumors, is a sequence-specific transcriptional activator. Recent studies have identified a p53 relative, termed p73. We were interested in determining the relative abilities of wild-type and mutant forms of p53 and p73alpha...
Topics
- Apoptosis
- Base Sequence
- Cell Line
- DNA-Binding Proteins
- Genes, Reporter
- Genes, Tumor Suppressor
- Humans
- Mutation
- Nuclear Proteins
- Plasmids
- Promoter Regions, Genetic
- Saccharomyces cerevisiae
- Transcriptional Activation
- Transfection
- Tumor Protein p73
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins