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Article

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

Molecular and cellular biology - 1 Feb 1999

Di Como C J, Gaiddon C, Prives C

Abstract excerpt

The p53 tumor suppressor protein, found mutated in over 50% of all human tumors, is a sequence-specific transcriptional activator. Recent studies have identified a p53 relative, termed p73. We were interested in determining the relative abilities of wild-type and mutant forms of p53 and p73alpha and -beta isoforms to transactivate various p53-responsive promoters. We show that both p73alpha and p73beta activate...

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Identifiers

PMID: 9891077
DOI: 10.1128/MCB.19.2.1438
PMCID: PMC116072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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