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Article

Genetic complementation of radiation response by 3' untranslated regions (UTR) of RNA.

International journal of radiation biology - 1 Mar 1996

Chen P, Girjes A A, Hobson K, Beamish H, Khanna K K, Farrell A, Gatei M, Teale B, Buchwald M, Legerski R, Lavin M F

Abstract excerpt

The molecular basis of radiosensitivity was studied using a cDNA complementation approach to correct radiosensitivity in cells. Four cDNAs of sizes 1.6, 2.0, 2.2 and 2.5 kb were isolated that corrected several aspects of the phenotype of cells from patients with the human genetic disorder ataxia-telangiectasia, characterized by hypersensitivity to ionizing radiation. The criteria used to assess correction...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8613688
DOI: 10.1080/095530096145940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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