E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

doi:10.1073/pnas.91.17.8263

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Article

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 1994

Larue L, Ohsugi M, Hirchenhain J, Kemler R

Abstract excerpt

The cell adhesion molecule E-cadherin mediates the compaction process of mouse preimplantation embryos and is important for the maintenance and function of epithelial cell layers. To determine precisely the role of E-cadherin in epithelial biogenesis we monitored the developmental potential of embryos homozygously negative for E-cadherin that were derived from E-cadherin heterozygous transgenic mice. The...

Topics

Animals
Base Sequence
Blastocyst
Cadherins
Ectoderm
Embryonic and Fetal Development
Epithelial Cells
Epithelium
Exons
Genes, Lethal
Genetic Vectors
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8058792
DOI: 10.1073/pnas.91.17.8263
PMCID: PMC44586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8058792-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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