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Article

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 1994

Larue L, Ohsugi M, Hirchenhain J, Kemler R

Abstract excerpt

The cell adhesion molecule E-cadherin mediates the compaction process of mouse preimplantation embryos and is important for the maintenance and function of epithelial cell layers. To determine precisely the role of E-cadherin in epithelial biogenesis we monitored the developmental potential of embryos homozygously negative for E-cadherin that were derived from E-cadherin heterozygous transgenic mice. The...

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Identifiers

PMID: 8058792
DOI: 10.1073/pnas.91.17.8263
PMCID: PMC44586

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