Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.

Molecular biology of the cell - 1 Aug 2007

Spencer Helen L, Eastham Angela M, Merry Catherine L R, Southgate Thomas D, Perez-Campo Flor, Soncin Francesca, Ritson Sarah, Kemler Rolf, Stern Peter L, Ward Christopher M

Abstract excerpt

Epithelial-mesenchymal transition (EMT) events occur during embryonic development and are important for the metastatic spread of epithelial tumors. We show here that spontaneous differentiation of mouse embryonic stem (ES) cells is associated with an E- to N-cadherin switch, up-regulation of E-cadherin repressor molecules (Snail and Slug proteins), gelatinase activity (matrix metalloproteinase [MMP]-2 and -9),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Surface

Share to Cell Communication

Share to Cytoskeleton

Share to Embryonic Stem Cells

Share to Matrix Metalloproteinases

Share to Mesoderm

Source

Open in PubMed Open full text

Identifiers

PMID: 17507657
DOI: 10.1091/mbc.e06-09-0875
PMCID: PMC1949355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.PMID 17507657Read ↗

The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotencySemantic proximity Read ↗

Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of TumorigenesisSemantic proximity Read ↗

Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation.Semantic proximity Read ↗

Downregulation of E-cadherin in pluripotent stem cells triggers partial EMTSemantic proximity Read ↗

Role of cell–cell adhesion complexes in embryonic stem cell biologySemantic proximity Read ↗

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.Semantic proximity Read ↗

Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells.Semantic proximity Read ↗

EpCAM is involved in maintenance of the murine embryonic stem cell phenotype.Semantic proximity Read ↗

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling.Semantic proximity Read ↗

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.Semantic proximity Read ↗

Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin.Semantic proximity Read ↗

E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.