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Article

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant.

Development (Cambridge, England) - 1 Apr 1994

Levine E, Lee C H, Kintner C, Gumbiner B M

Abstract excerpt

E-cadherin function was disrupted in vivo in developing Xenopus laevis embryos through the expression of a mutant E-cadherin protein lacking its cytoplasmic tail. This truncated form of E-cadherin was designed to act as a dominant negative mutant by competing with the extracellular interactions of wild-type endogenous E-cadherin. Expression of truncated E-cadherin in the early embryo causes lesions to develop in...

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Identifiers

PMID: 7600966
DOI: 10.1242/dev.120.4.901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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