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Article

Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin.

Development (Cambridge, England) - 1 Oct 2010

Stephenson Robert Odell, Yamanaka Yojiro, Rossant Janet

Abstract excerpt

The first two cell lineages in the mouse, the surface trophectoderm (TE) and inner cell mass (ICM), are morphologically distinguishable by E3.5, with the outer TE forming a polarized epithelial layer enclosing the apolar ICM. We show here that in mouse embryos completely lacking both maternal and zygotic E-cadherin (cadherin 1), the normal epithelial morphology of outside cells is disrupted, but individual cells...

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Identifiers

PMID: 20826529
DOI: 10.1242/dev.050195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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