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Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation

26 Oct 2011

Abstract excerpt

INTRODUCTION: E-cadherin (E-cad; cadherin 1) and N-cadherin (N-cad; cadherin 2) are the most prominent members of the cadherin family of cell adhesion molecules. Although they share many structural and functional features, they are expressed in an almost mutually exclusive manner in vivo. METHODS: To explore functional differences between the two cadherins in vivo, we recently generated a knock-in line in which...

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PMID: 22030022
DOI: 10.1186/bcr3046

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