Article
Proteolytic release of membrane proteins: studies on a membrane-protein-solubilizing activity in CHO cells.
Immunopharmacology - 1 Jun 1997
Ehlers M R, Schwager S L, Chubb A J, Scholle R R, Brandt W F, Riordan J F
Abstract excerpt
Diverse membrane proteins are solubilized by a specific proteolytic cleavage in the stalk sequence adjacent to the membrane anchor, with release of the extracellular domain. Examples are the amyloid precursor protein, membrane-bound growth factors and angiotensin-converting enzyme (ACE). The iden...
Topics
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Animals
- Aspartic Acid Endopeptidases
- CHO Cells
- Cricetinae
- Endopeptidases
- Humans
- Kinetics
- Matrix Metalloproteinases, Membrane-Associated
- Membrane Proteins
- Metalloendopeptidases
- Molecular Sequence Data
- Mutation
- Peptidyl-Dipeptidase A
- Recombinant Fusion Proteins
- Recombinant Proteins
- Solubility