The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families.

doi:10.1006/jaut.1994.1053

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Article

The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families.

Journal of autoimmunity - 1 Oct 1994

Pugliese A, Awdeh Z L, Alper C A, Jackson R A, Eisenbarth G S

Abstract excerpt

Several polymorphisms of the insulin gene and its flanking regions (INS region) are in linkage disequilibrium and confer susceptibility to insulin-dependent diabetes (IDDM). We have analysed INS AA and AB-BB genotypes at the 1,428 FokI site (3' of the insulin gene) in 217 patients with IDDM, 402...

Topics

Adult
Alleles
Autoantibodies
Autoimmune Diseases
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 1
Disease Progression
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genomic Imprinting
Humans
Insulin
Islets of Langerhans
Linkage Disequilibrium
Male
Nuclear Family
Parents

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Open in PubMed

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PMID: 7840860
DOI: 10.1006/jaut.1994.1053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7840860-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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