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Article

Additive susceptibility to insulin-dependent diabetes conferred by HLA-DQB1 and insulin genes.

Autoimmunity - 1 Jan 1994

She J X, Bui M M, Tian X H, Muir A, Wakeland E K, Zorovich B, Zhang L P, Liu M C, Thomson G, Maclaren N K

Abstract excerpt

Several genomic polymorphisms at the insulin (INS) gene and its flanking regions were analyzed in 197 unrelated Caucasian patients affected by insulin-dependent diabetes (IDDM) and 159 ethnically matched, normal controls ascertained from the South-Eastern United States. We found that the frequency of homozygotes for the common variant at the insulin gene was significantly increased in the diabetic population (RR...

Topics

Base Sequence
DNA
Diabetes Mellitus, Type 1
Electrophoresis, Polyacrylamide Gel
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Insulin
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 7858104
DOI: 10.3109/08916939409007996

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7858104-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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