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Article

Structure-function relationship of the small GTPase rab5.

The Journal of biological chemistry - 15 Nov 1993

Li G, Stahl P D

Abstract excerpt

Overexpression of rab5 via a Sindbis virus vector resulted in a 2-3-fold stimulation of horseradish peroxidase uptake in BHK-21 cells. Based on this functional assay of rab5 activity, we conducted extensive mutational analysis of the structure-function relationship of rab5. A total of 21 deletion and substitution mutations were created and their effects on rab5 activity were examined. Deletion of the entire...

Topics

Amino Acid Sequence
Cell Line
Conserved Sequence
Endocytosis
GTP Phosphohydrolases
GTP-Binding Proteins
Guanosine Diphosphate
Guanosine Triphosphate
Molecular Sequence Data
Mutation
Sequence Deletion

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Structure-Activity Relationship

rab5 GTP-Binding Proteins

Source

Identifiers

PMID: 8226999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8226999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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