Article
Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis.
Antimicrobial agents and chemotherapy - 1 Oct 1991
Sreedharan S, Peterson L R, Fisher L M
Abstract excerpt
gyrA mutations in quinolone-resistant pathogenic isolates of Staphylococcus spp. have been detected by the direct HinfI digestion of polymerase chain reaction products. Homology among gyrA genes allowed rapid examination of both coagulase-positive and -negative isolates. DNA sequence analysis revealed that ciprofloxacin resistance in Staphylococcus epidermidis is associated with a novel Ser-84----Phe mutation in...
Topics
- Anti-Infective Agents
- Base Sequence
- Ciprofloxacin
- Coagulase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Serine