Article
Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Applegate M L, Moore M M, Broder C B, Burrell A, Juhn G, Kasweck K L, Lin P F, Wadhams A, Hozier J C
Abstract excerpt
The mouse lymphoma L5178Y TK+/- 3.7.2C cell line allows quantitation of induced TK(+/-)----TK-/- mutations at the heterozygous thymidine kinase (Tk) locus. TK-/- mutant colonies show a bimodal size distribution, reflecting a difference in the growth rates of the two size classes that is hypothesi...
Topics
- Alleles
- Animals
- Chromosome Mapping
- DNA, Neoplasm
- Genes
- Genetic Carrier Screening
- Leukemia L5178
- Leukemia, Experimental
- Mice
- Mutation
- Polymorphism, Restriction Fragment Length
- Restriction Mapping
- Thymidine Kinase