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Article

Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Applegate M L, Moore M M, Broder C B, Burrell A, Juhn G, Kasweck K L, Lin P F, Wadhams A, Hozier J C

Abstract excerpt

The mouse lymphoma L5178Y TK+/- 3.7.2C cell line allows quantitation of induced TK(+/-)----TK-/- mutations at the heterozygous thymidine kinase (Tk) locus. TK-/- mutant colonies show a bimodal size distribution, reflecting a difference in the growth rates of the two size classes that is hypothesized to result from different degrees of genetic damage. The two homologous chromosomes 11 containing the alleles of the...

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Identifiers

PMID: 1967496
DOI: 10.1073/pnas.87.1.51
PMCID: PMC53197

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.PMID 1967496Read ↗

Sequence analysis of tka(-)-1 and tkb(+)-1 alleles in L5178Y tk+/- mouse-lymphoma cells and spontaneous tk-/- mutants.Semantic proximity Read ↗

Use of DNA purified in situ from cells embedded in agarose plugs for the molecular analysis of tk-/- mutants recovered in the L5178Y tk+/- 3.7.2C mutagen assay system.Semantic proximity Read ↗

Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk+/--3.7.2C Mouse Lymphoma Cells.Semantic proximity Read ↗

Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers.Semantic proximity Read ↗

Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.Semantic proximity Read ↗

Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.Semantic proximity Read ↗

Comparison of chromosome aberration frequency and small-colony TK-deficient mutant frequency in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.Semantic proximity Read ↗

Use of microsatellite DNA polymorphisms on mouse chromosome 11 for in vitro analysis of thymidine kinase gene mutations.Semantic proximity Read ↗

Molecular aspects of chemical mutagenesis in L5178Y/tk +/- mouse lymphoma cells.Semantic proximity Read ↗

The mouse lymphoma L5178Y Tk+/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene.Semantic proximity Read ↗

Loss of P53 heterozygosity is not responsible for the small colony thymidine kinase mutant phenotype in L5178Y mouse lymphoma cells.Semantic proximity Read ↗

In vitro mouse lymphoma (L5178Y Tk⁺/⁻-3.7.2C) forward mutation assay.Semantic proximity Read ↗

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