Article
Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells.
Mutagenesis - 1 Sept 1998
Clark L S, Hart D W, Vojta P J, Harrington-Brock K, Barrett J C, Moore M M, Tindall K R
Abstract excerpt
The thymidine kinase locus (Tk1) in Tk(+/-)-3.7.2C mouse lymphoma cells is widely used to identify mutagenic agents. Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents, we...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Codon
- Codon, Nonsense
- DNA, Neoplasm
- Exons
- Genes, p53
- Genetic Linkage
- Leukemia L5178
- Mice
- Molecular Sequence Data
- Mutagenicity Tests
- Mutation, Missense
- Neoplasm Proteins
- Point Mutation