Article
Impaired Th2 subset development in the absence of CD4.
Immunity - 1 May 1997
Fowell D J, Magram J, Turck C W, Killeen N, Locksley R M
Abstract excerpt
Prior studies in CD4-deficient mice established the capacity of T helper (Th) lineage cells to mature into Th1 cells. Unexpectedly, challenge of these mice with Nippostrongylus brasiliensis, a Th2-inducing stimulus, failed to result in the development of Th2 cells. Additional studies were performed using CD4+ or CD4-CD8- (double-negative) T cell receptor (TCR) transgenic T cells reactive to LACK antigen of...
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