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Article

Genetic basis of IgE responsiveness: relevance to the atopic diseases.

International archives of allergy and immunology - 1 Jan 2000

Marsh D G, Neely J D, Breazeale D R, Ghosh B, Freidhoff L R, Schou C, Beaty T H

Abstract excerpt

Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 x 10(-6)). These and...

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Identifiers

PMID: 7613143
DOI: 10.1159/000236920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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