Genetic basis of IgE responsiveness: relevance to the atopic diseases.

doi:10.1159/000236920

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Article

Genetic basis of IgE responsiveness: relevance to the atopic diseases.

International archives of allergy and immunology - 1 Jan 2000

Marsh D G, Neely J D, Breazeale D R, Ghosh B, Freidhoff L R, Schou C, Beaty T H

Abstract excerpt

Genetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 1...

Topics

Antibody Formation
Antibody Specificity
Chromosomes, Human, Pair 5
Consanguinity
Disease Susceptibility
Ethnicity
Gene Expression Regulation
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Interleukin-4
Th2 Cells

Source

Open in PubMed

Identifiers

PMID: 7613143
DOI: 10.1159/000236920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7613143-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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