Article
The genetics of asthma.
Current opinion in pulmonary medicine - 1 Jan 1998
Kim H S, Tsai P B, Oh C K
Abstract excerpt
The genetic approach to asthma has revealed a few candidate genes. Among them, special attention is given to the association between chromosome 5q and various cytokines and also to chromosome 11q and the IgE receptor. A mutation in chromosome 5 enhances interleukin-4 activity, which increases IgE synthesis by plasma cells. Polymorphism in the beta chain of the high-affinity IgE receptor (FC epsilonRI-beta) is...
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