Article
Molecular determinants of dysplasia in colorectal lesions.
Cancer research - 1 Nov 1994
Jen J, Powell S M, Papadopoulos N, Smith K J, Hamilton S R, Vogelstein B, Kinzler K W
Abstract excerpt
One hallmark of malignant potential is dysplasia, the disruption of normal morphology. While it is generally recognized that cancer is the result of a series of genetic changes, the relationship of these alterations and their timing to the advent of dysplasia remains obscure. To address this issu...
Topics
- Base Sequence
- Codon
- Colonic Polyps
- Colorectal Neoplasms
- Genes, APC
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Precancerous Conditions