Article
Molecular determinants of dysplasia in colorectal lesions.
Cancer research - 1 Nov 1994
Jen J, Powell S M, Papadopoulos N, Smith K J, Hamilton S R, Vogelstein B, Kinzler K W
Abstract excerpt
One hallmark of malignant potential is dysplasia, the disruption of normal morphology. While it is generally recognized that cancer is the result of a series of genetic changes, the relationship of these alterations and their timing to the advent of dysplasia remains obscure. To address this issue, 54 small benign colorectal lesions of various malignant potential were analyzed for APC and K-RAS mutations, two...
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