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Article

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

10 May 1994

Abstract excerpt

Human diploid fibroblast cells lose replicative potential after a certain number of population doublings. We use this experimental system to investigate the role of oxidative damage in cellular aging. Treating cells with H2O2 at < 300 microM did not affect the viability of the majority of cells when judged by morphology, trypan blue exclusion, and protein synthesis. However, the treatment caused a dose-dependent...

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PMID: 8183882
DOI: 10.1073/pnas.91.10.4130

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