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Article

Spontaneous In Vitro Immortalization of Breast Epithelial Cells from a Patient with Li-Fraumeni Syndrome

1 Jan 1995

Abstract excerpt

Individuals with germ line mutations in the p53 gene, such as Li-Fraumeni syndrome (LFS), have an increased occurrence of many types of cancer, including an unusually high incidence of breast cancer. This report documents that normal breast epithelial cells obtained from a patient with LFS (with a mutation at codon 133 of the p53 gene) spontaneously immortalized in cell culture while the breast stromal...

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PMID: 7799951
DOI: 10.1128/mcb.15.1.425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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