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Article

Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.

Oncogene - 25 Jun 2009

Morrison B H, Haney R, Lamarre E, Drazba J, Prestwich G D, Lindner D J

Abstract excerpt

Inositol hexakisphosphate kinase 2 (IP6K2), a member of the inositol hexakisphosphate kinase family, functions as a growth suppressive and apoptosis-enhancing kinase during cell stress. We created mice with a targeted deletion of IP6K2; these mice display normal embryogenesis, development, growth and fertility. Chronic exposure to the carcinogen 4-nitroquinoline 1-oxide (4-NQO, a UV-mimetic compound) in drinking...

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Identifiers

PMID: 19430495
DOI: 10.1038/onc.2009.113
PMCID: PMC3171149

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Source receipt: pubmed, retrieved 7 Sept 2026.

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